p53-mediated neurodegeneration in the absence of the nuclear protein Akirin2
Stacey L. Peek, Peter J. Bosch, Ethan Bahl, Brianna J. Iverson, Mrutyunjaya Parida, Preeti Bais, John Robert Manak, Jacob J. Michaelson, Robert W. Burgess, Joshua A. Weiner
This study shows that Akirin2 loss in excitatory cortical neurons leads to neurodegeneration via p53 activation, highlighting its role in neuronal maintenance and potential relevance to neurodegenerative diseases.
iScience · Jan 24, 2022Peer-reviewedNeuroscience