Ethan Bahl

NEUROeSTIMator: Using Deep Learning to Quantify Neuronal Activation from Single-Cell and Spatial Transcriptomic Data

NEUROeSTIMator uses deep learning to estimate neuronal activation from single-cell and spatial transcriptomic data, showing robustness across species and brain regions.

Mapping the spatial transcriptomic signature of the hippocampus during memory consolidation

This study uses spatial transcriptomics to identify distinct gene expression signatures in hippocampal subregions during memory consolidation and shows their functional relevance.

The gene expression signature of electrical stimulation in the human brain

This study identifies the gene expression changes in the human brain following electrical stimulation, revealing non-neuronal cell involvement and a conserved gene signature.

Clinical autism subscales have common genetic liabilities that are heritable, pleiotropic, and generalizable to the general population

The paper investigates the genetic liabilities of autism subscales, finding heritable, pleiotropic traits with sex-specific effects and stronger genetic signals in the RBS-R instrument.

Endoplasmic Reticulum Chaperone Genes Encode Effectors of Long-Term Memory

The paper identifies ER chaperone genes as effectors of long-term memory and shows their role in mitigating memory deficits in a tau-based ADRD mouse model.

p53-mediated neurodegeneration in the absence of the nuclear protein Akirin2

This study shows that Akirin2 loss in excitatory cortical neurons leads to neurodegeneration via p53 activation, highlighting its role in neuronal maintenance and potential relevance to neurodegenerative diseases.

Altered hippocampal transcriptome dynamics following sleep deprivation

This study identifies 1,146 dysregulated genes in the hippocampus following acute sleep deprivation, revealing distinct transcriptomic changes in RNA splicing, cell adhesion, and synaptic processes.

The CBP KIX domain regulates long-term memory and circadian activity

This study shows that the CBP KIX domain is essential for long-term memory and circadian rhythms by regulating CREB and CLOCK target genes.

Exome sequencing of 457 autism families recruited online provides evidence for novel ASD genes

The paper reports exome sequencing of 457 ASD families, identifying 10.4% with known ASD genes and 3.4% with possibly associated variants, and provides statistical support for 34 ASD risk genes using the TADA framework.