Joshua A. Weiner

PCDHGC3 silencing promotes renal carcinoma metastasis via mTOR/HIF2a and lipid metabolism rewiring

This study shows that silencing PCDHGC3 promotes renal carcinoma metastasis through mTOR/HIF2a activation and lipid metabolism changes.

A new mouse mutant with a discrete mutation in Pcdhgc5 reveals that the Protocadherin γC5 isoform is not essential for dendrite arborization in the cerebral cortex

The paper describes a mouse mutant lacking the Pcdhgc5 isoform, finding no major disruption in cerebral cortex development despite changes in synaptic-related pathways.

A C-terminal motif containing a PKC phosphorylation site regulates γ-Protocadherin-mediated dendrite arborization in the cerebral cortex in vivo

This study shows that phosphorylation of a shared C-terminal motif in γ-Protocadherin negatively regulates dendrite arborization in cortical neurons, with a C-terminal deletion causing the strongest phenotype.

The Clustered Gamma Protocadherin Pcdhγc4 Isoform Regulates Cortical Interneuron Programmed Cell Death in the Mouse Cortex.

The paper shows that deletion of the Pcdhγc4 isoform increases cortical interneuron cell death, while viral expression rescues it, highlighting its critical role in regulating survival during programmed cell death.

γ-Protocadherins control synapse formation and peripheral branching of touch sensory neurons

This study shows that γ-protocadherin isoforms are critical for synapse formation and peripheral branching in touch sensory neurons, and their loss disrupts corticospinal synapses.

p53-mediated neurodegeneration in the absence of the nuclear protein Akirin2

This study shows that Akirin2 loss in excitatory cortical neurons leads to neurodegeneration via p53 activation, highlighting its role in neuronal maintenance and potential relevance to neurodegenerative diseases.

CRISPR/Cas9 interrogation of the mouse Pcdhg gene cluster reveals a crucial isoform-specific role for Pcdhgc4

The paper uses CRISPR/Cas9 to disrupt isoforms of the Pcdhg gene cluster in mice, finding that Pcdhgc4 is the only critical isoform for neuronal function.