BiochemistrybioRxivPreprint
Crystal structure and molecular dynamics simulations of rademikibart Fab-IL-4Rα complex reveal biochemical basis for next-generation potent IL-4Rα inhibition in type 2 allergic and inflammatory diseases
Yuanjun Shi, Kelsey A Nolden, Minh Ho…·Christopher G. Bunick
This paper determines the crystal structure of rademikibart Fab-IL-4Rα complex and performs MD simulations to show its superior binding and inhibition of IL-4R compared to dupilumab.
DOI 10.64898/2026.04.12.718052