Author

Kelsey A Nolden

Medical College of WisconsinORCID 0000-0003-2235-7900Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Approach:mechanistic / dynamical model· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Elizabeth Wei-Chia LuoiD· 2 shared Gerard C. L. WongiD· 2 shared Haleh AlimohamadiiD· 2 shared Liting DuaniD· 2 shared R. Blake HilliD· 2 shared Christopher G. BunickiD· 1 shared Haote LiiD· 1 shared Michelle W. LeeiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiophysics

Elizabeth Wei-Chia LuoORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintApr 13, 2026

Crystal structure and molecular dynamics simulations of rademikibart Fab-IL-4Rα complex reveal biochemical basis for next-generation potent IL-4Rα inhibition in type 2 allergic and inflammatory diseases

Yuanjun Shi, Kelsey A Nolden, Minh Ho…·Christopher G. Bunick

This paper determines the crystal structure of rademikibart Fab-IL-4Rα complex and performs MD simulations to show its superior binding and inhibition of IL-4R compared to dupilumab.

DOI 10.64898/2026.04.12.718052

humanprotein structure

𝕏 PostBluesky

BiophysicsJournal of the American Chemical SocietyPeer-reviewedJul 8, 2025

Drp1 Proteins Released from Hydrolysis-driven Scaffold Disassembly Trigger Nucleotide-dependent Membrane Remodeling to Promote Scission

Elizabeth Wei-Chia Luo, Kelsey A Nolden, Haleh Alimohamadi…·Gerard C. L. Wong

The paper investigates the mechanism of mitochondrial fission by Drp1, showing that GTP hydrolysis enables free Drp1 to induce membrane negative Gaussian curvature, promoting scission.

4 citations

machine learning (classical)cell signaling & trafficking

𝕏 PostBluesky

BiophysicsJournal of the American Chemical SocietyPeer-reviewedJul 8, 2025

Dynamins combine mechano-constriction and membrane remodeling to enable two-step mitochondrial fission via a snap-through instability.

Haleh Alimohamadi, Elizabeth Wei-Chia Luo, Xiaoying Liu…·Gerard C. L. Wong

This study shows how dynamin proteins use mechano-constriction and membrane curvature to drive mitochondrial fission through a snap-through instability.

4 citations

mechanistic / dynamical modelcell signaling & trafficking

𝕏 PostBluesky