Molecular BiologybioRxivPreprint
Creatine synthesis is a tumor suppressor pathway hypostatic to one-carbon metabolism
Nicole Yong Ting Leung, Tiffany Melanie Yee, Roya AminiTabrizi…·Liang Wei Wang
The paper shows MTHFD2 supports creatine synthesis in PTLD models by driving glycine production, and its loss reveals tumor-suppressive effects through metabolic epistasis.
DOI 10.1101/2025.05.23.655758