Creatine synthesis is a tumor suppressor pathway hypostatic to one-carbon metabolism
Nicole Yong Ting Leung, Tiffany Melanie Yee, Roya AminiTabrizi, Ragini Bhalla, Nicholas Ang, Liangjian Lu, Chang‐Yien Chan, Derrick Wen Quan Lian, Matthew Y. Lim, João A. Paulo, Wei Wu, Hardik Shah, Liang Wei Wang
The paper shows MTHFD2 supports creatine synthesis in PTLD models by driving glycine production, and its loss reveals tumor-suppressive effects through metabolic epistasis.
bioRxiv · May 23, 2025 · PreprintMolecular Biology