Leona D. Samson

This study identifies persistent interferon signaling and clonal expansion as early events in NDMA-induced liver cancer by analyzing molecular changes in mice.

This study investigates sex differences in susceptibility to NDMA-induced mutations, toxicity, and cancer in mice, finding males are more prone to cancer while Aag overexpression increases toxicity, particularly in females.

This study shows that loss of Aag in mice reduces DNA damage and alters gene expression in the brain, leading to reduced anxiety and improved memory.

The paper introduces CometChip, a platform for high-throughput parallel analysis of multiple DNA repair activities, demonstrating its effectiveness in assessing repair deficiencies in Base Excision Repair, Nucleotide Excision Repair, and Non-Homologous End Joining.

The paper shows AAG associates with transcription elongation to coordinate DNA repair with gene expression, revealing roles of aberrantly methylated bases in gene regulation.