Barbara van Loon

A high-throughput screening dataset of small-molecule inhibitors across human DNA glycosylases

The paper establishes a high-throughput screening dataset of small-molecule inhibitors across nine human DNA glycosylases, identifying previously unreported inhibitors and making data publicly available.

Apurinic/apyrimidinic endodeoxyribonuclease 1 contributes to the repair of damaged intercalated-motif of telomeric sequences

This study investigates APE1's role in repairing damaged telomeric i-motif structures and its interaction with PCBP1 in maintaining telomere integrity.

Whole genome CRISPR knockout screen reveals ID3 as a key regulator of myeloma cell survival via TCF3 and c-MYC

Loss of alkyladenine DNA glycosylase alters gene expression in the developing mouse brain and leads to reduced anxiety and improved memory

This study shows that loss of Aag in mice reduces DNA damage and alters gene expression in the brain, leading to reduced anxiety and improved memory.

Persistence of Cajal-Retzius cells in the postnatal hippocampus is required for development of dendritic spines of CA1 pyramidal cells

This study shows that persistent Cajal-Retzius cells in the postnatal hippocampus are essential for the development of dendritic spines in CA1 pyramidal cells.

Uncoordinated long-patch base excision repair at juxtaposed DNA lesions generates a lethal accumulation of double-strand breaks

The paper shows that uncoordinated BER activity at DNA lesions causes DSB accumulation in yeast exposed to Zeocin, leading to genomic fragmentation.

Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression

The paper shows AAG associates with transcription elongation to coordinate DNA repair with gene expression, revealing roles of aberrantly methylated bases in gene regulation.