John M. Essigmann

Persistent interferon signaling and clonal expansion mark early events in DNA methylation damage-induced liver cancer

This study identifies persistent interferon signaling and clonal expansion as early events in NDMA-induced liver cancer by analyzing molecular changes in mice.

Systems analysis uncovers early temozolomide responses and peptide antigens in glioblastoma

This study uses a multi-omics approach to analyze early TMZ responses in GBM cells, identifying TMZ-associated peptide antigens and immune-related changes.

Sex and Alkyladenine DNA Glycosylase Expression are Key Susceptibility Factors for NDMA-induced Mutations, Toxicity, and Cancer

This study investigates sex differences in susceptibility to NDMA-induced mutations, toxicity, and cancer in mice, finding males are more prone to cancer while Aag overexpression increases toxicity, particularly in females.