Sota Yagi

This study investigates whether prebiotic cationic amino acids like ornithine and diamino butyric acid can support the formation of an ancient protein fold, finding that they can adopt a foldable structure under specific conditions.

This study shows that restricting amino acid diversity can replace native enzymatic activity with an alternative phosphoryl-transfer reaction in a reconstructed ancestral nucleoside diphosphate kinase.

This study uses ancestral sequence reconstruction to identify amino acid substitutions responsible for low-temperature adaptation in an enzyme.