A comparative analysis of BrdU and EdU genotoxicity shows that trypanosomatids exhibit unique responses to the presence of these thymidine analogs in their DNA
Marcos Antonio Fernandes de Oliveira, Vitor Luiz da Silva, Thaise Lara Teixeira, Fernanda Merchiori Gerolamo, Tarcillo J. N. Gaziri, Jennifer Ann Black, Fernanda de Jesus Silva, Hernan Chaimovich, Iolanda Midea Cuccovia, Marcelo S. da Silva
This study compares the genotoxic effects of BrdU and EdU in trypanosomatids, finding EdU more genotoxic and revealing species-specific responses to DNA damage.
bioRxiv · Nov 3, 2026 · PreprintMolecular Biology