Vitor Luiz da Silva

A comparative analysis of BrdU and EdU genotoxicity shows that trypanosomatids exhibit unique responses to the presence of these thymidine analogs in their DNA

This study compares the genotoxic effects of BrdU and EdU in trypanosomatids, finding EdU more genotoxic and revealing species-specific responses to DNA damage.

Reduced levels of inositol hexakisphosphate kinase (IP6K) impair life-cycle transitions and the intracellular development of Trypanosoma cruzi within human cardiomyocytes

This study shows that reducing IP6K levels in T. cruzi impairs key life-cycle transitions and intracellular development in human cardiomyocytes, suggesting IP6K as a potential drug target for Chagas disease.

Cryptic Sex in Leishmania Depends on SPO11 Paralogs

This study identifies the roles of SPO11 paralogs in Leishmania hybridization, showing they are essential for efficient mating and genome segregation.