Marcelo S. da Silva

This study compares the genotoxic effects of BrdU and EdU in trypanosomatids, finding EdU more genotoxic and revealing species-specific responses to DNA damage.

This study shows that reducing IP6K levels in T. cruzi impairs key life-cycle transitions and intracellular development in human cardiomyocytes, suggesting IP6K as a potential drug target for Chagas disease.

This study characterizes NAT10 in Leishmania mexicana, showing its nuclear localization, essentiality, and role in parasite differentiation and metabolism.

The paper analyzes nascent transcriptomes of Trypanosoma cruzi to show asymmetric transcriptional abundance and links it to genome organization, chromatin status, and cis-acting elements.

The paper shows that transcription activity triggers non-constitutive origins in Trypanosoma brucei to ensure timely DNA replication.