Author

Anne H. Klein

Commonwealth Scientific and Industrial Research OrganisationORCID 0000-0002-7165-0049Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:machine learning (classical)· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:GWAS summary statistics· 1 Assay:proteomics· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Brendan HoskingiD· 2 shared Denis C. BaueriD· 2 shared Michael J. KuiperiD· 2 shared Natalie A. TwineiD· 2 shared Roc ReguantiD· 2 shared Yatish JainiD· 2 shared Angus Panagopoulos· 1 shared Anubhav KaphleiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCancer Biology

Brendan HoskingORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintNov 5, 2025

Machine Learning-Driven Discovery of Synergistic Protein Interactions Identifies ATL3 as a Putative Biomarker for Cancer Drug Response

Priya Ramarao-Milne, Anubhav Kaphle, Roc Reguant…·Denis C. Bauer

The paper introduces synerOmics, a machine learning framework to identify synergistic protein interactions, finding ATL3 as a biomarker for lapatinib resistance in breast cancer.

DOI 10.1101/2025.11.05.686871

humanproteomics

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Genetic & Genomic MedicinemedRxivPreprintOct 19, 2025

Novel Epistatic Interaction Between RBMS3 and CDKN2B-AS1 in Coronary Artery Disease Risk Identified by Machine Learning Tool VariantSpark

Letitia M.F. Sng, Mitchell J. O’Brien, Brendan Hosking…·Natalie A. Twine

The paper identifies an epistatic interaction between RBMS3 and CDKN2B-AS1 in CAD risk using VariantSpark and BitEpi, with validation in UK Biobank and All of Us.

DOI 10.1101/2025.10.19.25338331

humanGWAS summary statistics

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