Author

Michael J. Kuiper

Commonwealth Scientific and Industrial Research OrganisationORCID 0000-0002-8213-8382Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Cancer Biology· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:machine learning (classical)· 2 Organism:mouse· 2 Research Focus:variant effect prediction· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Denis C. BaueriD· 3 shared Anne H. KleiniD· 2 shared Brendan HoskingiD· 2 shared Letitia M.F. SngiD· 2 shared Natalie A. TwineiD· 2 shared Priya Ramarao-MilneiD· 2 shared Roc ReguantiD· 2 shared Yatish JainiD· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersBioinformatics

Denis C. BauerORCID

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4 papers

Recent·Most cited

BioinformaticsbioRxivPreprintJul 10, 2026

Evaluating the cross-species transferability and scaling of sequence-to-function predictions in AlphaGenome

Priya Ramarao-Milne, Suyu Ma, Letitia M.F. Sng…·Denis C. Bauer

The paper evaluates AlphaGenome's cross-species performance on mouse data, showing varying accuracy for different functional tasks and introduces a confidence scoring method for AI predictions.

DOI 10.64898/2026.07.10.737654

mousehuman

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Cancer BiologybioRxivPreprintNov 5, 2025

Machine Learning-Driven Discovery of Synergistic Protein Interactions Identifies ATL3 as a Putative Biomarker for Cancer Drug Response

Priya Ramarao-Milne, Anubhav Kaphle, Roc Reguant…·Denis C. Bauer

The paper introduces synerOmics, a machine learning framework to identify synergistic protein interactions, finding ATL3 as a biomarker for lapatinib resistance in breast cancer.

DOI 10.1101/2025.11.05.686871

humanproteomics

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Genetic & Genomic MedicinemedRxivPreprintOct 19, 2025

Novel Epistatic Interaction Between RBMS3 and CDKN2B-AS1 in Coronary Artery Disease Risk Identified by Machine Learning Tool VariantSpark

Letitia M.F. Sng, Mitchell J. O’Brien, Brendan Hosking…·Natalie A. Twine

The paper identifies an epistatic interaction between RBMS3 and CDKN2B-AS1 in CAD risk using VariantSpark and BitEpi, with validation in UK Biobank and All of Us.

DOI 10.1101/2025.10.19.25338331

humanGWAS summary statistics

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BioinformaticsILAR JournalPeer-reviewedJan 1, 2021

But Mouse, you are not alone: On some severe acute respiratory syndrome coronavirus 2 variants infecting mice

Michael J. Kuiper, Laurence O W Wilson, Shruthi Mangalaganesh…·Seshadri S. Vasan

The paper identifies SARS-CoV-2 variants that can infect mice and suggests targeted surveillance in specific countries due to potential human-mouse virus transmission.

14 citations

mousestatistical model

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