ImmunologyCancer ResearchPeer-reviewed
SMARCA4 mutation induces tumor cell-intrinsic defects in enhancer landscape and resistance to immunotherapy
Yawen Wang, Ismail Mustafa Meraz, Md Qudratullah…·Yonathan Lissanu
This study shows that SMARCA4 mutations in lung cancer disrupt enhancer landscapes and innate immune gene expression, leading to immunotherapy resistance.
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