Jack A. Roth

This study identifies PI3K-mTOR pathway inhibition as a strategy to overcome acquired resistance to KRASG12C inhibitors in NSCLC by targeting 4E-BP1.

This study shows that SMARCA4 mutations in lung cancer disrupt enhancer landscapes and innate immune gene expression, leading to immunotherapy resistance.

The paper presents a pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis of tumor regions and xenograft-transplant lymphoproliferative disorder prediction.

CombPDX evaluates drug synergism in PDX models using tumor growth curves and provides statistical metrics and inference procedures for combination effects.