Pharmacology & ToxicologybioRxivPreprint
Nuclear α1A-Adrenergic Receptor Regulation of cAMP Production by an Inside-Out MAP Kinase Signaling Pathway in Cardiac Myocytes
Chase M. Fiore, Michael W. Rudokas, Riko Masuda…·Robert D. Harvey
The paper shows that nuclear α1A-adrenergic receptors inhibit βAR-mediated cAMP production via an inside-out MAPK signaling pathway in cardiac myocytes, revealing a novel mechanism of sympathetic signaling interaction.
DOI 10.1101/2025.11.20.687712