Nuclear α1A-Adrenergic Receptor Regulation of cAMP Production by an Inside-Out MAP Kinase Signaling Pathway in Cardiac Myocytes
Chase M. Fiore, Michael W. Rudokas, Riko Masuda, Brandon Khamsopha, Rinzhin Tshering Sherpa, Karni Singh Moshal, Shailesh R. Agarwal, Robert D. Harvey
The paper shows that nuclear α1A-adrenergic receptors inhibit βAR-mediated cAMP production via an inside-out MAPK signaling pathway in cardiac myocytes, revealing a novel mechanism of sympathetic signaling interaction.
bioRxiv · Nov 20, 2025 · PreprintPharmacology & Toxicology