Michael W. Rudokas

Nuclear α1A-Adrenergic Receptor Regulation of cAMP Production by an Inside-Out MAP Kinase Signaling Pathway in Cardiac Myocytes

The paper shows that nuclear α1A-adrenergic receptors inhibit βAR-mediated cAMP production via an inside-out MAPK signaling pathway in cardiac myocytes, revealing a novel mechanism of sympathetic signaling interaction.

Transient AMPK activation by nutrient stress of high fat diet preserves cardiac electrophysiological stability and protects against arrhythmias

This study shows that AMPK activation by high-fat diet reduces arrhythmia risk by improving cardiac electrophysiology and mitochondrial function.