The paper harmonizes clinical interpretations of cancer genomic variants across six knowledgebases, improving overlap and matching with patient cohorts.

Nature Genetics · Apr 1, 2020Peer-reviewedBioinformatics

A pan-cancer landscape of interactions between solid tumors and infiltrating immune cell populations

David Tamborero, Carlota Rubio-Pérez, Ferran Muiños, Radhakrishnan Sabarinathan, Josep Maria Piulats, Aura Muntasell, Rodrigo Dienstmann, Núria López-Bigas, Abel González-Pérez

This study identifies genomic and transcriptomic traits associated with immune-phenotypes in 9,403 solid tumors across 29 cancers, revealing patterns linked to immune evasion and tumor progression.

Clinical Cancer Research · Apr 17, 2018Peer-reviewedBioinformatics

Discovery and characterization of coding and non-coding driver mutations in more than 2,500 whole cancer genomes

Esther Rheinbay, Morten Muhlig Nielsen, Federico Abascal, Grace Tiao, Henrik Hornshøj, Julian M. Hess, Randi Istrup Pedersen, Lars Feuerbach, Radhakrishnan Sabarinathan, Tobias Lynge Madsen, Jaegil Kim, Loris Mularoni, Shimin Shuai, Andrés Lanzós, Carl Herrmann, , Gad A. Getz

The paper identifies and characterizes coding and non-coding driver mutations across 2,500 cancer genomes, revealing new candidates and questioning previous findings.

bioRxiv · Dec 23, 2017 · PreprintGenomics

The whole-genome panorama of cancer drivers

Radhakrishnan Sabarinathan, Oriol Pich, Iñigo Martincorena, Carlota Rubio-Perez, Malene Juul, Jeremiah Wala, Steven Schumacher, Ofer Shapira, Nikos Sidiropoulos, Sebastian M. Waszak, David Tamborero, Loris Mularoni, Esther Rheinbay, Henrik Hornshøj, Jordi Deu-Pons, , on behalf of the PCAWG Drivers and Functional Interpretation Group and the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Network

This paper identifies driver mutations across 2,500 tumors from 37 cancer types, revealing a whole-genome panorama of genomic events that underlie tumor development.

bioRxiv · Dec 23, 2017 · PreprintCancer Biology