David Peter De Souza

This study shows that muscle-specific PolG dysfunction causes mitochondrial dysfunction and cachexia by activating the mtISR and altering the mitochondrial folate cycle.

The paper identifies a lipid signature associated with BAK-driven apoptotic pore formation and shows cholesterol inhibits pore formation by preventing BAK clustering.

The paper compares matrix, deposition technique, and polarity settings in MALDI-TOF mass spectrometry imaging for brain tumors, finding recrystallized cyano-4-hydroxycinnamic acid in positive polarity provides best performance.