Shannen Walker

This paper demonstrates that injectable antisense oligonucleotides (ASO) can prevent and treat obesity in mice without significant loss of lean mass.

This study shows that biological sex and nitric oxide synthase inhibition lead to different cardiac responses to cardiometabolic stress in older mice, resulting in distinct HFpEF-like or HFrEF-like phenotypes.

This study shows that impairing polymerase gamma activity in cardiomyocytes leads to mtDNA instability, activates the integrated stress response, and causes severe cardiomyopathy with hepatopathy in mice.

This study shows that muscle-specific PolG dysfunction causes mitochondrial dysfunction and cachexia by activating the mtISR and altering the mitochondrial folate cycle.