Olafur B. Davidsson

Combining genome-wide polygenic scores with registry data for colorectal cancer risk-based screening

This study evaluates polygenic risk scores (PRS) for colorectal cancer (CRC) screening, showing they stratify risk independently of ancestry and sex but offer limited additional predictive value when combined with FIT.

Genetic liability for endometriosis associates with pain, inflammatory, and metabolic traits: a polygenic score analysis

This paper uses a polygenic risk score to show that genetic liability for endometriosis is linked to pain, inflammatory, and metabolic traits in both sexes.

Genetic predisposition to mosaic Y chromosome loss in blood is associated with genomic instability in other tissues and susceptibility to non-haematological cancers

The paper identifies genetic determinants of mosaic Y chromosome loss in blood and links it to genomic instability and non-haematological cancer risk.

Mutations in RPL3L and MYZAP increase risk of atrial fibrillation

This study identifies mutations in RPL3L and MYZAP as risk factors for atrial fibrillation through genome-wide association analysis and functional validation.