Author

Hanna Davies

Uppsala UniversityORCID 0000-0002-6289-3815Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 6 Genetics· 2 Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 10 Approach:statistical model· 10 Research Focus:differential expression· 7 Assay:bulk RNA-seq· 5 Research Focus:gene regulatory network inference· 3 Assay:whole-exome sequencing· 3 Assay:DNA methylation· 2 Approach:experimental assay· 2

Frequent Co-Authors

Jan Piotr DumanskiiD· 10 shared Edyta Rychlicka-BuniowskaiD· 6 shared Natalia H. FilipowicziD· 6 shared Arkadiusz PiotrowskiiD· 5 shared Bożena Bruhn‐OlszewskaiD· 5 shared Jakub MieczkowskiiD· 5 shared Marcin JąkalskiiD· 5 shared Martin IngelssoniD· 5 shared

Activity by Year

2019-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

10 shared papersGenetic & Genomic Medicine

Jan Piotr DumanskiORCID

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10 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintJun 5, 2025

Loss of Y chromosome in Alzheimer disease patients co-occurs with clonal hematopoiesis defined by post-zygotic point mutations outside canonical CHIP driver genes

Edyta Rychlicka-Buniowska, Daniil Sarkisyan, Monika Horbacz…·Jan Piotr Dumanski

The paper investigates the relationship between loss of Y chromosome (LOY) and clonal hematopoiesis in Alzheimer's disease patients, finding that LOY drives myeloid clones which may accumulate additional mutations.

1 citation

humanwhole-exome sequencing

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Genetic & Genomic MedicinemedRxivPreprintOct 4, 2024

Beyond Tumors: Reduced survival linked to pathogenic PIK3CA and TP53 post-zygotic variants in the uninvolved breast tissue of recurrent cancer patients

Maria Andreou, Katarzyna Chojnowska, Natalia H. Filipowicz…·Arkadiusz Piotrowski

The paper identifies pathogenic post-zygotic variants in normal breast tissue of poor-prognosis cancer patients, linking them to reduced survival and disease recurrence.

DOI 10.1101/2024.10.04.24313634

humanwhole-exome sequencing

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GenomicsInternational Journal of CancerPeer-reviewedJun 8, 2024

Prelude to Malignancy: A Gene Expression Signature in Normal Mammary Gland from Breast Cancer Patients Suggests Pre-tumorous Alterations and Is Associated with Adverse Outcomes

Maria Andreou, Marcin Jąkalski, Katarzyna Duzowska…·Arkadiusz Piotrowski

4 citations

humanbulk RNA-seq

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Genetic & Genomic MedicineScientific ReportsPeer-reviewedApr 24, 2024

Loss of Y in regulatory T lymphocytes in the tumor micro-environment of primary colorectal cancers and liver metastases

Magdalena Wójcik, Ulana Juhas, Elyas Mohammadi…·Jan Piotr Dumanski

The paper investigates LOY in TME leukocytes, finding higher LOY frequency in Tregs and its association with immune checkpoint receptor expression.

23 citationstop 4%

humanbulk RNA-seq

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Genetic & Genomic MedicinemedRxivPreprintFeb 7, 2023

Loss of Y is associated with multi-omic changes in immune cells from Alzheimer's disease patients

Marcin Jąkalski, Edyta Rychlicka-Buniowska, Hanna Davies…·Jakub Mieczkowski

The paper identifies multi-omic changes in immune cells from Alzheimer's disease patients with loss of Y, linking LOY to epigenetic and gene expression alterations.

2 citations

humanDNA methylation

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Genetic & Genomic MedicineGenome MedicinePeer-reviewedDec 13, 2022

Loss of Y in leukocytes as a risk factor for critical COVID-19 in men

Bożena Bruhn‐Olszewska, Hanna Davies, Daniil Sarkisyan…·Jan Piotr Dumanski

The paper investigates LOY in leukocytes as a risk factor for severe COVID-19 in men, finding higher LOY levels in critical cases and associations with immune-related outcomes.

30 citations

humanbulk RNA-seq

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Genetic & Genomic Medicinenpj Breast CancerPeer-reviewedJun 29, 2022

High prevalence of somatic PIK3CA and TP53 pathogenic variants in the normal mammary gland tissue of sporadic breast cancer patients revealed by duplex sequencing.

Anna Kostecka, Tomasz Nowikiewicz, Paweł Olszewski…·Arkadiusz Piotrowski

27 citations

humanwhole-exome sequencing

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BioinformaticsbioRxivPreprintMar 31, 2022

Size matters - the impact of nucleus size on results from spatial transcriptomics

Elyas Mohammadi, Katarzyna Chojnowska, Michał Bieńkowski…·Jakub Mieczkowski

This study investigates how nucleus size affects spatial transcriptomics results and introduces CSDI to improve accuracy in analyzing consecutive tissue slices.

DOI 10.1101/2022.03.31.486657

humanspatial transcriptomics

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GeneticsbioRxivPreprintMay 11, 2019

Intra-individual changes in the frequency of mosaic loss of chromosome Y over time estimated with a new method

Marcus Danielsson, Jonatan Halvardson, Hanna Davies…·Lars Anders Forsberg

The paper introduces a method to estimate intra-individual changes in mosaic loss of chromosome Y (LOY) over time using standardized SNP-array data, showing higher correlation with other methods and significant individual variation.

3 citations

humanwhole-genome sequencing

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GeneticsbioRxivPreprintJan 8, 2019

Genetic predisposition to mosaic Y chromosome loss in blood is associated with genomic instability in other tissues and susceptibility to non-haematological cancers

Deborah J. Thompson, Giulio Genovese, Jonatan Halvardson…·John R. B. Perry

The paper identifies genetic determinants of mosaic Y chromosome loss in blood and links it to genomic instability and non-haematological cancer risk.

6 citations

humanbulk RNA-seq

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