A New Approach to Modeling LGMDR1: Pyrvinium-Treated capn3b crispant Zebrafish
Cristina Ruiz‐Roldán, Andrea Valls, Jenita Immanuel, Flavia De Santis, Roberto Fernández‐Torrón, López de Munain Adolfo, Amets Sáenz
The paper develops a pharmacologically enhanced zebrafish model of LGMDR1 by treating capn3b mutants with pyrvinium, mimicking human gene expression patterns and highlighting Wnt pathway involvement.
bioRxiv · Nov 25, 2025 · PreprintMolecular Biology