This study examines differences in 6PPD-Q biotransformation and metabolome responses among early-life stage salmonids, finding that brown trout detoxify it more effectively than sensitive species.

Environmental Science & Technology · Jul 7, 2025Peer-reviewedPharmacology & Toxicology

Sub-chronic and acute toxicity of 6PPD-quinone to early-life stage rainbow trout (Oncorhynchus mykiss)

Catherine Roberts, Evan Kohlman, Niteesh Jain, Mawuli Amekor, Alper James Alcaraz, Natacha Hogan, Markus Brinkmann, Markus Hecker

This study assesses the acute and sub-chronic toxicity of 6PPD-quinone to early-life stage rainbow trout, finding higher sensitivity compared to sub-adults and developmental abnormalities.

Environmental Science & Technology · Mar 27, 2025Peer-reviewedPharmacology & Toxicology

Acute and sub-chronic toxicity of 6PPD-quinone to early-life stage lake trout (Salvelinus namaycush)

Catherine Roberts, Junyi Lin, Evan Kohlman, Niteesh Jain, Mawuli Amekor, Alper James Alcaraz, Natacha Hogan, Markus Hecker, Markus Brinkmann

This study assesses the acute and sub-chronic toxicity of 6PPD-quinone to early-life stage lake trout, finding significant mortality and deformities at environmentally relevant concentrations.

Environmental Science & Technology · Jan 3, 2025Peer-reviewedPhysiology

Underlying molecular effects to behavioral consequences present line of evidence for zebrafish eye development and function alteration by crude oil exposure.

Leonie K. Mueller, Sarah Johann, Bernd Denecke, Ali Taleb Abdallah, Markus Hecker, Henner Hollert, Thomas‐Benjamin Seiler

This study shows crude oil exposure reduces zebrafish embryo eye size and swimming activity, with molecular and histological evidence linking these effects to gene dysregulation and retinal structural changes.

bioRxiv · Jan 23, 2024 · PreprintDevelopmental Biology