Gut Microbe-Derived N-Acyl Serinol Lipids Shape Host Postprandial Metabolic Homeostasis
Sumita Dutta, Kala K. Mahen, William J. Massey, Venkateshwari Varadharajan, Amy C Burrows, Anthony J. Horak, Marko Mrdjen, Nour Mouannes, Danny Orabi, Lucas J. Osborn, Treg M. Grubb, Rachel C. Hohe, Rakhee Banerjee, Vinayak Uppin, Dev Laungani, , Jonathan Mark Brown
This study identifies N-acyl amides from gut microbes as regulators of postprandial metabolic homeostasis by affecting host hormones, gene expression, and microbiome composition.
Proceedings of the National Academy of Sciences · Mar 19, 2026Peer-reviewedPhysiology