Modeling human age-associated increase in Gadd45γ expression leads to spatial recognition memory impairments in young adult mice
David V.C. Brito, Kübra Gülmez Karaca, Janina Kupke, Franziska Mudlaff, Benjamin Zeuch, Rui Gomes, Luísa Vaqueiro Lopes, Ana M.M. Oliveira
This study shows that increased Gadd45γ expression in the hippocampus of aged humans and young adult mice impairs spatial memory and disrupts CREB signaling and activity-regulated genes.
Neurobiology of Aging · Jul 3, 2020Peer-reviewedNeuroscience