Janina Kupke

Hippocampal DNA methylation promotes memory persistence by facilitating systems consolidation and cortical engram stabilisation.

This study identifies hippocampal DNA methylation as a mechanism that converts short-lasting into long-lasting memories by promoting systems consolidation and cortical engram stabilization.

Dnmt3a1 regulates hippocampus-dependent memory via the downstream target Nrp1

This study shows that Dnmt3a1, but not Dnmt3a2, is required for hippocampus-dependent memory through its regulation of Nrp1.

Biphasic Npas4 expression promotes inhibitory plasticity and suppression of fear memory consolidation in mice

This study shows that biphasic Npas4 expression suppresses fear memory consolidation and promotes behavioral flexibility in mice by facilitating fear extinction.

Engram reactivation during memory retrieval predicts long-term memory performance in aged mice

This study shows that engram reactivation during memory retrieval predicts long-term memory performance in aged mice, with impaired reactivation linked to cognitive decline.

MeCP2 gates spatial learning-induced alternative splicing events in the mouse hippocampus

This study identifies MeCP2's role in regulating alternative splicing in the mouse hippocampus during spatial learning and shows its impact on memory consolidation and Rett syndrome pathophysiology.

Modeling human age-associated increase in Gadd45γ expression leads to spatial recognition memory impairments in young adult mice

This study shows that increased Gadd45γ expression in the hippocampus of aged humans and young adult mice impairs spatial memory and disrupts CREB signaling and activity-regulated genes.