Thomas A. Wynn

Combination antagonism of TNF superfamily signaling for T cell immunosuppression

This study evaluates TNF/TNFR combinations for immunosuppression, finding that four drug combinations significantly reduce T cell cytokine production and gene activation in allogeneic responses.

Myeloid cells contribute to bystander CD8 T cell accumulation in metabolic-associated steatohepatitis and are sufficient for fibrosis

This study shows myeloid cells, not conventional T cells, drive fibrosis in MASH by retaining CD8 T cells in the fibrotic niche.

L-Cells are the Functional Neuropod Cell in Human Gastrointestinal Tract and are Dysregulated in Inflammatory Bowel Disease (IBD)

This study identifies L-cells as human neuropod cells in the colon and shows their dysregulation in IBD.

Therapeutic Blockade of Type 2 Cytokines and PD1 Unleashes Anti-Tumor Immunity Through Coordinated Reprogramming of Innate and Adaptive Immune Surveillance

This study shows that blocking type 2 cytokines and PD1 enhances anti-tumor immunity by reprogramming immune cells in both in vitro and in vivo models.