Philipp Kaldis

IL-32 is a stress-responsive node locked in a noncanonical NF-κB inflammatory loop during MASLD to HCC transition

This paper identifies a noncanonical NF-κB-driven IL-32 loop that promotes inflammation during MASLD to HCC transition, revealing IL-32's dual role in metabolism and inflammation.

Global molecular landscape of early MASLD progression in obesity

This study identifies molecular changes in early MASLD progression in obesity through transcriptomic and metabolomic analyses, revealing distinct metabolic pathways and novel gene targets for liver fibrosis.

Differential splice isoforms of mouse CDK2 play functionally redundant roles during mitotic and meiotic division

This study shows that CDK2L and CDK2S isoforms are functionally redundant in supporting both mitotic and meiotic divisions in mice.

CDK2 kinase activity is a regulator of male germ cell fate

This study shows that CDK2 kinase activity regulates male germ cell fate by controlling the balance between stem cell renewal and differentiation, with loss of function leading to infertility.