Andrew Grimson

The paper identifies two rodent-specific transposable element subfamilies that function as cell-type-specific enhancers in the mouse immune system, contributing to cell identity and gene regulation.

The paper identifies novel neonatal CD8β+ T cell subsets (FITs) with innate-like features, distinct from conventional and unconventional T cells, using cord blood samples.

This study constructs a transcriptional and epigenetic atlas of T cell development in neonatal and adult mice, identifying age-related gene regulatory programs and a conserved regulator, Zbtb20.

This study uses a deep learning framework to analyze whole-genome data from ME/CFS patients, identifying risk genes and linking them to disease symptoms and other complex traits.

This study compares neonatal and adult CD8+ recent thymic emigrants using single-cell multiomics, finding distinct phenotypes and functions despite similar post-thymic maturation.

This study shows AGO3 and AGO4 regulate transcriptional silencing of XY-linked genes during meiosis in spermatogenesis, impacting fertility and sperm morphology.

The paper identifies gene regulatory programs distinguishing naive CD8+ T cell subsets using RNA-seq and ATAC-seq data, revealing novel regulators and transcriptional networks.

The paper identifies a novel regulatory pathway that represses transcripts with long 3'UTRs through accelerated RNA decay, independent of sequence elements or transcript length.

This paper introduces CARP, a method combining RNA-seq and PRO-seq to distinguish direct miRNA targets from downstream regulatory changes, showing improved accuracy and reduced false positives.

This study uses single-cell RNA sequencing to analyze transcriptional changes in spermatogonia and spermatocytes across developmental stages, revealing age-related gene expression differences and pathway utilization.

This study shows that 3' sequence identity is not required for the established function of miR-146a in myeloid cells in vivo.

This study shows that CDK2 kinase activity regulates male germ cell fate by controlling the balance between stem cell renewal and differentiation, with loss of function leading to infertility.