Novel MAPK/AKT-impairing germline NRAS variant identified in a melanoma-prone family
Kevin M. Brown, Mai Xu, Michael R. Sargen, Hyunbum Jang, Mingzhen Zhang, Tongwu Zhang, Bin Zhu, Kristie Jones, Jung Kim, Laura Mendoza, Nicholas K. Hayward, Margaret Anne Tucker, Alisa M. Goldstein, Xiaohong Rose Yang, Douglas R. Stewart, , Maria Teresa Landi
The paper identifies a novel NRAS variant in a melanoma-prone family and shows it impairs MAPK/AKT signaling while enhancing PI3K signaling.
Familial Cancer · Jul 2, 2021Peer-reviewedGenetic & Genomic Medicine