BiophysicsCommunications ChemistryPeer-reviewed
Oncogenic PI3Kα variants reveal graded conformational spectrum with mutation-specific cryptic pockets
Hyunbum Jang, Bengi Ruken Yavuz, Mingzhen Zhang…·Ruth Nussinov
The paper uses molecular dynamics simulations to show that double mutations in PI3K variants lead to more active conformations and drug-targetable cryptic pockets, suggesting a conformational selection strategy for drug development.
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