Design and Biophysical Characterization of Second-Generation Cyclic Peptide LAG-3 Inhibitors for Cancer Immunotherapy
Laura Calvo‐Barreiro, Longfei Zhang, Yasir Ali, Ashfaq Ur Rehman, Moustafa Tarek Gabr
The paper designs and characterizes second-generation cyclic peptide LAG-3 inhibitors, identifying cyclic peptide 12 as the most effective with an IC50 of 4.45 µM.
Bioorganic & Medicinal Chemistry Letters · Sep 26, 2024Peer-reviewedPharmacology & Toxicology