Site-specific combinatorial ubiquitination drives the targeted degradation of plasma membrane proteins
Niclas Olsson, Aleksandr Gaun, Sammy Villa, Katrina L. Jackson, Mark E. Fitzgerald, Fiona Elizabeth McAllister, David Stokoe, Aaron H. Nile, Kirill Bersuker
This study identifies ubiquitination sites on RTKs that mediate their degradation via CRLs and shows that multiple ubiquitination sites are required for effective degradation.
bioRxiv · May 27, 2026 · PreprintCell Biology