Aleksandr Gaun

A multiomic lifespan signature in genetically diverse, diet-restricted mice

This study identifies molecular changes in diet-restricted mice that correlate with lifespan and aging, highlighting key genes and pathways involved in longevity.

Site-specific combinatorial ubiquitination drives the targeted degradation of plasma membrane proteins

This study identifies ubiquitination sites on RTKs that mediate their degradation via CRLs and shows that multiple ubiquitination sites are required for effective degradation.

Platform-dependent effects of genetic variants on plasma APOL1

The paper identifies platform-dependent effects of APOL1 variants on plasma levels measured by different proteomic technologies.

Automated preparation of plasma lipids, metabolites, and proteins for LC/MS-based analysis of a high-fat diet in mice

The paper describes an automated LLE platform for plasma sample preparation and analyzes metabolomic, lipidomic, and proteomic changes in mice on a high-fat diet.

Precise Estimation of In Vivo Protein Turnover Rates

This paper introduces a new framework to estimate in vivo protein turnover rates by addressing labeling identification and amino acid enrichment challenges, revealing differences in protein turnover between mice and naked mole-rats.