Cellular and Molecular Resolution of Focal Segmental Glomerulosclerosis Recurrence in Human Allografts
Lorenzo G. Gallon, Haseeb Zubair, Thomas V. Rousselle, Amol Carl Shetty, Shafquat Azim, Elissa Bardhi, Eleonora Forte, Cinthia Beskow Drachenberg, Enver Akalin, Manish Talwar, Jonathan S. Bromberg, Daniel G. Maluf, Valeria R. Mas
This study uses snRNA-seq to analyze kidney transplant biopsies and identifies molecular and cellular mechanisms of recurrent FSGS, including podocyte loss and PEC dedifferentiation.
bioRxiv · Apr 24, 2025 · PreprintMolecular Biology