The paper identifies small RNA biomarkers, including tRFs and miRNAs, associated with IRI and EAD in liver transplantation using tissue and perfusate samples.

Computational and Structural Biotechnology Journal · Jan 1, 2026Peer-reviewedGenomics

Unveiling APOL1 Haplotypes: A Novel Classification Through Probe-Independent Quantitative Real-Time PCR

Murat Doğan, Christine E. Watkins, Holly Ingram, Nicholas D Moore, Grace M. Rucker, Elizabeth G. Gower, James D. Eason, Anshul Bhalla, Manish Talwar, Nosratollah Nezakatgoo, Corey Eymard, Ryan A. Helmick, Jason M. Vanatta, Amandeep Bajwa, Canan Kuscu, Cem Kuscu

This study develops a probe-independent qPCR method to identify APOL1 variants in kidney transplant recipients and assesses their impact on transplant outcomes.

bioRxiv · Oct 16, 2023 · PreprintGenetics

The role of ANGIOGENIN, or lack thereof, in the generation of stress-induced tRNA halves and of smaller tRNA fragments that enter Argonaute complexes

Zhangli Su, Canan Kuscu, Asrar Ahmad Malik, Etsuko Shibata, Anindya Dutta

This study shows ANG cleaves specific tRNAs to produce halves and tRF-5s, but stress-induced tRNA halves are mostly ANG-independent, and tRF-3s are not generated from tRNA halves or ANG cleavage.

Journal of Biological Chemistry · Oct 3, 2019Peer-reviewedMolecular Biology

Global Gene Repression By Dicer-Independent tRNA Fragments

Canan Kuscu, Pankaj Kumar, Manjari Kiran, Zhangli Su, Asrar Ahmad Malik, Anindya Dutta

The paper identifies tRF-3 fragments that repress gene expression through Argonaute-dependent seed sequence matching, independent of Dicer.

RNA · May 29, 2018Peer-reviewedMolecular Biology