ImmunologyPNAS NexusPeer-reviewed
Proinsulin C-peptide is a major source of HLA-DQ8 restricted HIPs recognized by human Islet-Infiltrating CD4+ T cells
Pushpak Bhattacharjee, Miha Pakusch, Matthew Lacorcia…·Stuart I. Mannering
This study identifies 13 new proinsulin-derived HIPs recognized by human islet-infiltrating CD4+ T cells in T1D, highlighting proinsulin C-peptide's central role in HIP formation.
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