Author

Brandon K. Tan

Washington University in St. LouisORCID 0000-0002-7291-793XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

Hanrui XuiD· 2 shared Wayland W.L. ChengiD· 2 shared Grace H. BranniganiD· 1 shared Jesse W. SandbergiD· 1 shared Vikram DalaliD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 8 mutual co-author links

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2 shared papersBiophysics

Hanrui XuORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintOct 7, 2025

Structural mechanism of lipid modulation of pentameric ligand-gated ion channel activity

Brandon K. Tan, Hanrui Xu, Jesse W. Sandberg…·Wayland W.L. Cheng

The paper investigates how specific lipids modulate the activity of the pLGIC ELIC5, showing that cardiolipin stabilizes an agonist-responsive resting state through binding at an M3-M4 site.

DOI 10.1101/2025.10.07.680764

structural biologyexperimental assay

𝕏 PostBluesky

BiophysicseLifePeer-reviewedJul 16, 2025

Cryo-EM structures of a pentameric ligand-gated ion channel in liposomes

Vikram Dalal, Brandon K. Tan, Hanrui Xu, Wayland W.L. Cheng

This study determines the cryo-EM structures of ELIC in liposomes, revealing the desensitization gate and showing that liposomes better capture functional states than nanodiscs.

2 citations

cryo-EMexperimental assay

𝕏 PostBluesky