Alena Kozlova

The paper identifies context-specific genetic effects in neuronal activation using single-cell multiomics, revealing NPD risk variants and genes active during stimulation.

The paper identifies an AD protective allele of CLU that enhances neuronal excitability via lipid-droplet-mediated neuron-glia communication.

The paper identifies OTUD7A loss-of-function mutations in schizophrenia-associated 15q13.3 deletions and shows they impair synapse development and function in human neurons.

The paper identifies multiple genes in cis regulated by a chromatin accessibility variant that contribute to synaptic dysfunction in human neurons associated with schizophrenia.

The paper introduces MetaChrom, a deep transfer learning framework for predicting epigenomic functions of genetic variants in neurodevelopment, showing improved accuracy over existing methods.

The paper identifies allele-specific open chromatin (ASoC) variants in human iPSC-derived neurons and shows their strong enrichment in brain disorder risk variants.