Siwei Zhang

Impacts of different SETD1A mutations and genetic backgrounds on human induced pluripotent stem cell-derived hippocampal neurons

This study examines how different SETD1A mutations and genetic backgrounds affect human hippocampal neurons derived from hiPSCs, revealing divergent molecular and cellular phenotypes and contrasting mutation impacts.

Single-cell multiomics of neuron activation reveals context-specific genetics of brain disorders

The paper identifies context-specific genetic effects in neuronal activation using single-cell multiomics, revealing NPD risk variants and genes active during stimulation.

Female iPSC X-chromosome inactivation (XCI) erosion and its transcriptomic effects during CRISPR gene editing and neural differentiation

The paper investigates XCI erosion in CRISPR-edited female iPSCs and their derived neurons, showing variable erosion in iPSCs and preserved XIST effects on gene expression in neurons.

Ethanol induces neuroimmune dysregulation and soluble TREM2 generation in a human iPSC neuron, astrocyte, microglia triculture model

This study shows ethanol exposure in a human iPSC-derived triculture model increases TREM2 expression and soluble TREM2 through alternative splicing, suggesting a link to neuroimmune dysregulation in alcohol use disorders.

Comparative Analysis of Neonatal Hypomyelination Models Using Spatial Transcriptomics

This study compares the effects of intermittent hypoxia and hypoxia-ischemia models on myelination in neonatal mice using spatial transcriptomics, finding region-specific differences in oligodendrocyte populations and inflammatory responses.

Polygenic Risk for Alcohol Use Disorder Affects Cellular Responses to Ethanol Exposure in a Human Microglial Cell Model

This study examines how polygenic risk scores for Alcohol Use Disorder affect microglial responses to ethanol exposure in human iPSC-derived microglia.

Mutations of schizophrenia risk gene SETD1A dysregulate synaptic function in human neurons

This study investigates how rare mutations in the SETD1A gene affect human neurons, showing they disrupt synaptic function and may contribute to schizophrenia pathophysiology.

Scaled and Efficient Derivation of Loss of Function Alleles in Risk Genes for Neurodevelopmental and Psychiatric Disorders in Human iPSC

The paper develops a pipeline for efficient loss-of-function mutagenesis in NPD genes using base editing in hiPSCs, achieving high reproducibility and confirming neural phenotypes.

Alzheimer's disease protective allele of Clusterin modulates neuronal excitability through lipid-droplet-mediated neuron-glia communication

The paper identifies an AD protective allele of CLU that enhances neuronal excitability via lipid-droplet-mediated neuron-glia communication.

Loss-of-function of OTUD7A in the schizophrenia-associated 15q13.3 deletion impairs synapse development and function in human neurons

The paper identifies OTUD7A loss-of-function mutations in schizophrenia-associated 15q13.3 deletions and shows they impair synapse development and function in human neurons.

Multiple genes in cis mediate the effects of a single chromatin accessibility variant on aberrant synaptic development and function in human neurons

The paper identifies multiple genes in cis regulated by a chromatin accessibility variant that contribute to synaptic dysfunction in human neurons associated with schizophrenia.

Transcriptomic signatures of sex-specific nicotine sensitization and imprinting of self-administration in rats inform GWAS findings on human addiction phenotypes

Predicting Epigenomic Functions of Genetic Variants in the Context of Neurodevelopment via Deep Transfer Learning

The paper introduces MetaChrom, a deep transfer learning framework for predicting epigenomic functions of genetic variants in neurodevelopment, showing improved accuracy over existing methods.

Allele-specific open chromatin in human iPSC neurons elucidates functional non-coding disease variants

The paper identifies allele-specific open chromatin (ASoC) variants in human iPSC-derived neurons and shows their strong enrichment in brain disorder risk variants.

Deconvolution of Transcriptional Networks Identifies TCF4 as a Master Regulator in Schizophrenia

The paper deconvolves transcriptional networks in schizophrenia to identify TCF4 as a master regulator potentially dysregulated in the disease.