An Atlas of Human and Murine Genetic Influences on Osteoporosis
John A. Morris, John P. Kemp, Scott E. Youlten, Laetitia Laurent, John G. Logan, Ryan Chau Chia Chai, Nicholas A. Vulpescu, Vincenzo Forgetta, Aaron Kleinman, Sindhu T. Mohanty, C. Marcelo Sergio, Julian M.W. Quinn, Loan Nguyen‐Yamamoto, Aimée-Lee Luco, Jinchu Vijay, , John Brent Richards
This paper identifies 518 genetic loci associated with bone mineral density and fracture risk, validates causal genes in mice, and provides insights for osteoporosis drug development.
Nature Genetics · Dec 17, 2018Peer-reviewedGenomics