Ryan Chau Chia Chai

The paper identifies key cell types and genes involved in skeletal disease using single-cell analysis and validates their roles in mouse models.

ENTRAIN integrates trajectory inference with gene regulatory networks to identify environmental signals driving cell fate by co-localizing receptor-ligand interactions in spatial data.

The paper maps the osteocyte transcriptome in mice, identifies 1239 genes, and links them to skeletal disease susceptibility in humans.

This paper identifies 518 genetic loci associated with bone mineral density and fracture risk, validates causal genes in mice, and provides insights for osteoporosis drug development.