Author

Patrick H. van Berkel

ADC Therapeutics (UK) Ltd , London ,ORCID 0000-0002-7315-0347Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:protein sequence· 1 Assay:proteomics· 1

Frequent Co-Authors

Adam J. WolpawiD· 1 shared Aimy SebastianiD· 1 shared Alaa Narch· 1 shared Alvin FarreliD· 1 shared Anilkumar GopalakrishnapillaiiD· 1 shared Chi Van DangiD· 1 shared David GroffiD· 1 shared Dirk HeckliD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Adam J. WolpawORCID

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2 papers

Recent·Most cited

DLK1 is a GATA1s-Driven Dependency and Therapeutic Target in Down Syndrome-Associated Myeloid Leukemia

Lonneke Verboon, Sonali P. Barwe, Meredith Tavenner, Joshua R. Faust, Hasan Issa, José Gonçalves-Dias, K. Schuschel, Raj Bhayadia, Patrick H. van Berkel, Aimy Sebastian, Rhonda E. Ries, Sophie Paczesny, Soheil Meshinchi, Johann K. Hitzler, Yana Pikman, , Anilkumar Gopalakrishnapillai

This study identifies DLK1 as a GATA1s-driven dependency in Down syndrome-associated myeloid leukemia, showing it as a therapeutic target with preclinical efficacy in PDX models.

Blood Advances · Apr 7, 2026Peer-reviewedCancer Biology

Lineage-dependence of the neuroblastoma surfaceome defines tumor cell state-dependent and independent immunotherapeutic targets

Nathan M. Kendsersky, Michal Odrobina, Nathaniel W. Mabe, Alvin Farrel, Liron D. Grossmann, Matthew Tsang, David Groff, Adam J. Wolpaw, Alaa Narch, Francesca Zammarchi, Patrick H. van Berkel, Chi Van Dang, Yaël P. Mossé, Kimberly Stegmaier, John M. Maris

This paper identifies cell state-dependent and -independent immunotherapeutic targets in neuroblastoma by analyzing subtype-specific gene expression and validating targets through experimental methods.

Neuro-Oncology · Jan 17, 2025Peer-reviewedCancer Biology