Stratification of TAD boundaries identified in reproducible Hi-C contact matrices reveals preferential insulation of super-enhancers by strong boundaries
Yixiao Gong, Charalampos Lazaris, Theodore Sakellaropoulos, Aurelie C. Lozano, Prabhanjan Kambadur, Panagiotis Ntziachristos, Iannis Aifantis, Aristotelis Tsirigos
The paper improves Hi-C contact matrix reproducibility using fused two-dimensional lasso, identifies TAD boundaries with varying insulation strength, and shows super-enhancers are preferentially insulated by strong boundaries, which are frequently co-duplicated in cancer.
Nature Communications · Feb 1, 2018Peer-reviewedBioinformatics