Yixiao Gong

The paper identifies lncRNAs involved in melanoma growth and metastasis using CRISPR-inhibition screens and validates their functional roles.

This study shows that reducing EHMT1/2 activity during reprogramming with ascorbic acid impairs iPSC formation and viability, highlighting the role of H3K9 methylation in reprogramming efficiency.

The paper improves Hi-C contact matrix reproducibility using fused two-dimensional lasso, identifies TAD boundaries with varying insulation strength, and shows super-enhancers are preferentially insulated by strong boundaries, which are frequently co-duplicated in cancer.

lncRNA-screen is a pipeline for computationally screening lncRNAs in large genomics datasets, generating interactive reports for further experimental validation.